Metroid Prime is a video game developed by Retro Studios and published by Nintendo for the Nintendo GameCube, released in North America on November 17, 2002.

In Super Smash Bros Brawl

The first location the player visits in the game, Frigate Orpheon, is a stage in Super Smash Bros Brawl. Also, the Parasite Queen, a boss from the game, appears as a background character.

Meta-Ridley, the cybernetic version of Ridley in the Subspace Emissary, first appeared in this game.

The credits/main menu theme is an available song in the Frigate Orpheon stage. The Meta-Ridley battle theme is also available on the same stage.

Trophies from the game include the Sheegoth, and the creature and final boss of the game, the Metroid Prime (exoskeleton and core as two separate trophies).