The player has 1 stock, while their foes, Master Hand and Crazy Hand, have 300 HP each. They are fought in Final Destination. The hands are at the same strength as they are on the Normal difficulty in Classic Mode. Unlike in Classic Mode, Crazy Hand is in the fight right away, instead of entering the fight when Master Hand's HP falls below the halfway point. As a result, this battle with Master and Crazy Hand is more difficult than the fight with them in Classic Mode.
When playing as Master Hand through the use of the Master Hand glitch, the background stays the same throughout the match.