Dr. Mario was an arcade-style puzzle video game produced by Nintendo. It was originally released for the Nintendo Entertainment System and Game Boy in 1990. Its gameplay is often likened to that of Tetris. In this game, Dr. Mario throws vitamins that the player must align in order to destroy the viruses that populate the playing field (designed to resemble a medicine bottle). It is also a confirmed title to be available on Wii's Virtual Console.
Super Smash Bros. Melee
The titular character of the this game is an unlockable character in Super Smash Bros. Melee. In addition, the fever tune is also his theme music, and the Viruses and Megavitamins from the game have trophies (See Viruses (Trophy) and Megavitamin (trophy)).