Dr. Mario (ドクターマリオ, Doctor Mario) is a 1990 puzzle video game for the Nintendo Entertainment System and the Game Boy. In the game, Mario, in his Dr. Mario persona, uses vitamins to destroy three different types of viruses by lining up three vitamins the same color as the virus, bearing some similarities with Tetris. The Game Boy version of the game appears in Super Smash Bros. for Wii U as a Masterpiece, and must be unlocked by clearing 10-Man Smash with Dr. Mario without taking damage.
The titular character of the this game is an unlockable character in Super Smash Bros. Melee. In addition, the Fever tune is also his theme music, and the Viruses and Megavitamins from the game have trophies.