User blog comment:KirbiMiroir/Clones 4 CA$H/@comment-27665259-20160221200757/@comment-12498802-20160222073441

Okay!

Basically, here's the deal - Mario is faster than his Doctor counterpart but doesn't have quite as much power. Additionally, Mario's Up Special lands lots of small hits whilst Dr. Mario's Up Special lands one big hit. Also, whilst Mario uses the FLUDD for his Down Special, Dr. Mario uses a spin attack.